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The highest tacrolimus level preceeded the rise in serum creatinine in 20 cases by an interval of 1.6 ± 1.8 d. A mean reduction in tacrolimus dosage of 41% ± 21% (range 11–89) led to a 86% ± 18% (range 45–100) fall in the serum creatinine within 1–14 d (p<0.001).
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